MALDI TOF system

Autof MS1000, Automated mass spectrometry microbial

maldi-tof and tof/tof ms The analytical advantages of matrix assisted laser desorption ionization (MALDI) TOF MS have been demonstrated for more than 25 years. With inherent benefits including its speed (time to results) and application flexibility, the convenience and effectiveness of MALDI-TOF MS is magnified by virtue of its low sample volume requirements and broad sample content (salts, buffers) amenability MALDI-TOF MS Systems. The AXIMA Microorganism Identification System presents a new solution for the identification of microorganisms for microorganism research in the pharmaceutical, food, science, energy, environment, clinical and health fields. QuickView The MALDI-TOF system for microbiology testing is the optimal solution for in-house microbial identification needs. The MALDI-TOF identification system instrument combined with validated microbial databases provides all of the tools needed for accurate and fast organism identifications


MALDI-TOF, eigentlich MALDI-TOF-Massenspektrometrie oder kurz MALDI, ist die Bezeichnung für eine bestimmte Form der Massenspektrometrie. Der volle Name ist Matrix-assisted laser desorption time-of-flight-Massenspektrometrie. Im engeren Sinne ist damit die Identifikation von Bakterien mit dieser Methode gemeint The Active Dryer is an important element of the automation for MALDI-TOF-MS sample preparation. By enabling controlled crystallization conditions, the active dryer allows faster sample preparation and creation of extremely homogeneous sample spots. Smart accessories perfectly supply the needs of MALDI sample preparatio

Grundlagen der MALDI-TOF-Massenspektrometrie . Was bedeutet MALDI? MALDI ist die Abkürzung für Matrix Assisted Laser Desorption/Ionization. Für die MALDI-MS Analyse wird die Probenlösung mit einer Matrixlösung vermischt und auf einem Probenträger aufgebracht. Je nach Fragestellung und Analyt finden sich die unterschiedlichsten Substanzen wie bspw. HCCA oder DHB, die als Matrix. Das aktuelle VITEK ® MS Software-Update umfasst eine Datenbankerweiterung zur Identifizierung von Mykobakterien, Nocardia und Schimmelpilzen* - dadurch wird es zum ersten MALDI-TOF MS (Matrix Assisted Laser Desorption Ionization Time-of-Flight Mass Spectrometry), das für diese klinisch relevanten Spezies die IVD/CE-Kennzeichnung besitzt Cost-effective, highly accurate system is applicable to a wide range of microorganisms System provides a seamless Lean workflow with the DxM MicroScan WalkAway System and MicroScan WalkAway plus Make every minute count Gold-standard MALDI-TOF technology provides rapid identification of isolate VITEK® MS PRIME ist eine neue Generation des VITEK® MS Systems zur Identifizierung von Mikroorganismen, das 2011 eingeführt wurde. VITEK® MS PRIME ist ein Massen-spektrometer zur Identifizierung von Mikroorganismen mit Hilfe der MALDI-TOF Technologie (Matrix Assisted Laser Desorption Ionization Time-of-Flight) (MALDI-TOF) The MALDI Biotyper ® is a modular system designed to be configured according to individual laboratory needs. Bruker offers laboratories the choice of the microbial MALDI-TOF mass spectrometer that best fits their needs. Continuous hardware development has led to the 4th generation of Bruker´s benchtop MALDI Biotyper ® system

MALDI-TOF MS Systems : SHIMADZU (Shimadzu Corporation

MALDI-TOF MS was first approved for clinical use in China in 2012 when bioMérieux VITEK MS system was approved by China State FDA for in vitro diagnostic (IVD) purposes (Luo et al., 2015). Later, China State FDA also approved the Bruker IVD MALDI Biotyper System for routine identification of microorganisms isolated from human specimens MALDI-TOF mass spectrometry is highly accurate. 4,7,8. The accuracy of the Bruker MALDI Biotyper as a microorganism identification system, together with its associated libraries, is considered comparable to 16S rRNA gene sequencing (the gold standard) and is globally recognized as the clinical laboratory standard for microbial identification MALDI TOF mass spectrometer In mass spectrometry, matrix-assisted laser desorption/ionization (MALDI) is an ionization technique that uses a laser energy absorbing matrix to create ions from large molecules with minimal fragmentation The easy-to-use iD Plus Microbial Identification System is the ideal tool to address these concerns. With iD Plus, cultured microorganisms can be directly applied to the MALDI sample target and introduced to an AXIMA series MALDI-TOF mass spectrometer to revolutionize the daily routine in analytical and diagnostic laboratories Variable performance between MALDI-TOF MS systems has been observed for Ochrobactrum anthropi, Elizabethkingia meningoseptica and the emerging pathogen Inquilinus limosus (Almuzara et al., 2015, Jamal, Albert and Rotimi, 2014). MALDI-TOF MS outperforms traditional identification methods and has lower misidentification rates for the identification of fastidious Gram-negative bacteria (Powell.

The MALDI-TOF Mass Spectrometry System market report offers a huge stage providing different gateways for different firms, organizations, new businesses, and affiliations. This MALDI-TOF Mass Spectrometry System report moreover comprises authorized predictions to design a better idea for the organizations We evaluated the applicability of matrix-assisted laser desorption/ionization time-of-flight mass spectrometry (MALDI-TOF MS) system, MicroIDSys Elite (ASTA Corp., South Korea) for the identification of medically important filamentous fungi. A total of 505 strains comprising 37 genera and 90 species collected from 11 Korean hospitals were sent to the microbiology laboratory of International St. Mary's Hospital. All isolates were tested using MicroIDSys Elite, and data were analyzed using the. MALDI-TOF system is a soft ionization technique that allows ionization and vaporization of large nonvolatile biomolecules such as intact proteins [ 8 ] Kubo, A., et al., Structural analysis of triacylglycerols by using a MALDI-TOF/TOF system with monoisotopic precursor selection. Journal of the American Society for Mass Spectrometry, 2013. 24(5): p. 684-689. Matsumori, N., et al., A Novel Sperm-Activating and Attracting Factor from the Ascidian Ascidia sydneiensis. Organic Letters, 2013. 15(2): p. 294-297. Teramoto, K., et al., Simple and.

Microbial Identification via MS / MALDI-ToF - Eurofins

Entdecken Sie alle Informationen zu Identifizierungssystem für Bakterien / Typ MALDI-TOF Axcess® MALDI-TOF ID System von der Firma Charles River Laboratories. Kontaktieren Sie einen Zulieferer oder direkt das Stammhaus und erhalten Sie einen Preis oder ein Angebot und entdecken Sie die Verkaufsstellen in Ihrer Nähe MALDI-TOF MS technique is a successful method of detecting microorganisms that have been widely used in microbiological laboratories in recent years [38-40]. MALDI-TOF MS is a device that generates ions from a sample and then separates the generated ions based on the mass-to-charge ratio in the gas phase MALDI-TOF. Matrix-Assisted Laser Desorption/Ionization Time-Of-Flight. AUTOMATED MASS SPECTROMETRY MICROBIAL IDENTIFICATION SYSTEM. Identification of microorganisms to the species level is the principle objective in microbiology. For many years, such a feat has been accomplished through laborious biochemical assays MALDI mass spectrometry imaging (MALDI-MSI) is the use of matrix-assisted laser desorption ionization as a mass spectrometry imaging technique in which the sample, often a thin tissue section, is moved in two dimensions while the mass spectrum is recorded. Advantages, like measuring the distribution of a large amount of analytes at one time without destroying the sample, make it a useful. MALDI-TOF measures the mass of molecules from a sample that has been embedded in a matrix by using a laser to ablate and desorb the molecules with minimal fragmentation. 1 The sample's molecules are ionized in the resultant hot plume of ablated gases and are funneled into a TOF mass spectrometer that records the ions' mass-to-charge (m/z) ratio. This is achieved by measuring the time the.

Axcess® MALDI-TOF Microbial Identification System

We have greatly enhanced the capacity and speed of our microbial identification capabilities by acquiring a MALDI-ToF (Matrix-assisted laser desorption/ioniz.. Matrix-assisted laser desorption ionization-time of flight mass spectrometry (MALDI-TOF MS) has been accepted as a rapid, accurate, and less labor-intensive method in the identification of microorganisms in clinical laboratories. However, there is limited data on systematic evaluation of its effectiveness in the identification of phylogenetically closely-related yeast species. In this study, we evaluated two commercially available MALDI-TOF systems, Autof MS 1000 and Vitek MS, for the. Matrix-Assisted Laser Desorption/Ionization-Time Of Flight (MALDI-TOF) mass spectrometry (MS) is a common method used for quality control (QC) of oligonucleotides. MALDI-TOF instrumentation is suitable for use in high-throughput industrial QC settings and can resolve molecules in the size range of oligonucleotides

MALDI-TOF - DocCheck Flexiko

MALDI-TOF/TOF Massenspektrometer System Fachliche Zuordnung Pflanzenwissenschaften Förderung Förderung in 2021 Projektkennung Deutsche Forschungsgemeinschaft (DFG) - Projektnummer 469113358 . Projektbeschreibung; Die Arbeitsgruppe der Antragstellerin ist seit vielen Jahren auf die Identifizierung und funktionell-strukturelle Charakterisierung von mobilen Proteinen aus Pflanzen spezialisiert. MALDI-TOF, eigentlich MALDI-TOF-Massenspektrometrie oder kurz MALDI, ist die Bezeichnung für eine bestimmte Form der Massenspektrometrie. Der volle Name ist Matrix-assisted laser desorption time-of-flight-Massenspektrometrie. Im engeren Sinne ist damit die Identifikation von Bakterien mit dieser Methode gemeint. Diese Anwendung hat in den vergangenen Jahren große klinische Bedeutung.

MALDI-TOF-MS Analytik Jena Gmb

Now when a MALDI-TOF analyzes a bacterial sample, a computer can match the resulting map to that of a known species with accuracy equal to that of microbiology's old system. In traditional clinical microbiology, researchers streak a sample onto an agar plate and try to identify microorganisms with several different biochemical tests. Best case scenario, this takes 24 hours, but it takes. MALDI - TOF MS is used in the field of biochemistry to identify the proteins and characterize it because protein contains a molecular weight that has an intact structure that becomes fragmented when ionized. Peptide mass fingerprinting (PMF): Peptide mass fingerprinting is used in the identification of proteins from simple mixture where MALDI - TOF plays an important role by its simple.

Grundlagen der MALDI-TOF-Massenspektrometri

MALDI-TOF MS User Platform . J. Rau 1, T. Eisenberg 2, R. Sting 1. 1 Chemisches und Veterinäruntersuchungsamt Stuttgart 2 Landesbetrieb Hessisches Landeslabor Gießen. Deutsch English Español. Eine offene Liste für Anwender. Die MALDI-TOF-Massenspektrometrie (MALDI-TOF MS) zeigt eine rasant steigende Verbreitung in vielen Anwendungsgebieten der Lebensmitteluntersuchung, der. Mikrobielle AccuPRO-ID ® MALDI-TOF-Identifizierungsprozesse sind cGMP-konform und ISO-17025-akkreditiert. Höhere Leistung gegenüber vorhandenen phänotypischen und sonstigen MALDI-TOF-Systemen dank relevanter mikrobieller Datenbanken. Nachweisliche Verbesserung der Genauigkeit (30 %-40 %) gegenüber phänotypischen Identifizierungssystemen Die MALDI-TOF-MS kombiniert die Matrixunterstützte Laser- Desorption/Ionisation (MALDI) mit einer Flugzeitmassenspektrometrie (TOF-MS). Die Technik zeigt eine rasant steigende Verbreitung auf vielen Gebieten der Lebensmitteluntersuchung. Am CVUA Stuttgart wurde nun eine erste eigene Datenbank für die Tierartbestimmung von Fleisch erstellt. Die MALDI-TOF-MS wird bisher hauptsächlich zur.

MALDI-TOF-MS-Diagnostik Die MALDI-TOF-MS-Diagnostik beruht auf der Analyse des Proteinprofils mehrheitlich von ribosomalen Proteinen. Da deren Sequenz mit der für sie codierenden DNA korreliert, ähnelt sie eher einem 16S-rDNA-Sequenzvergleich. So wird verständlich, dass das MALDI-TOF-MS-System nicht in der Lage ist, sehr eng ver MALDI - TOF mass spectrometer Shimadzu AXIMA CFR CIC-MALDI 1.1 UMDS - This document CIC-MALDI 1.2 MALDI - Basic Description & Generic Sample Preparation CIC-MALDI 1.3 New User Tutorial & Basic Axima Operation, Quick Use Notes CIC-MALDI 1.4 AXIMA - System Maintenance CIC-MALDI 1.5 AXIMA - Calibration Performance Testing. 2 USER & MATERIAL DATA SHEET CHEMICAL INSTRUMENTATION CENTER.

Die MALDI-TOF-Massenspektrometer umfassen verschiedene Gerätetypen, angefangen vom einfachen linearen Typ bis hin zu High-End CID Geräten. Dabei werden die Systeme einer Vielzahl verschiedener Anwendungen gerecht und bieten so maximale Flexibilität unterschiedlichster Aufgabenstellungen MALDI-TOF/TOF mass spectrometry An Introduction Contact : ms.support.us@bruker.com Phone: 978-663-3660 Ext 5 Bruker MALDI-TOF(/TOF) Portfolio: • microflex LT : Bench-top systems, 60 Hz nitrogen laser, • autoflex speed: Floor standing, various configuration available (lin, ref, TOF/TOF), 2KHz for MS, 200Hz for MSMS; • ultrafleXtreme: Top-of-the-line instrument, 2000 Hz MS, 1000 Hz for.

VITEK® MS: Erstes MALDI-TOF-System mit IVD/CE

  1. Another method for the identification of M. tuberculosis from MGIT positive bottles using the VITEK MS (bioMérieux, Marcy l'Étoile, France) MALDI-TOF system has been described
  2. SpiralTOF MALDI-ToF System. JEOL USA have introduced of the company's first commercially available MALDI-ToF mass spectrometer, the JEOL JMS-S3000 SpiralTOF. The SpiralTOF has new ToF ion optics with an extended flight length in a compact footprint, delivering a resolving power of greater than 60,000 (FWHM) over a wide mass range of m/z 10.
  3. a und homogene MALDI-Spots . Ein.
  4. Lieferumfang: (Massenspektrometer-System wie abgebildet) 2 Wochen Inbetriebnahme Garantie Das Gerät kommt aus einer Lagerauflösung. Wir liefern auch mit Express-Versand / express shipping (DHL, UPS, TNT) Weitere Fragen können wir gerne am Telefon für Sie beantworten. Schriftliche Bestellung möglich per Email oder Fa

Another study suggested that MALDI-TOF MS is the method of choice for the identification of Campylobacter and related microorganisms compared with other commercial systems . For Gram-negative bacteria evaluation, there are 2263 clinical significant species can be analyzed by MALDI-TOF MS identification. Faron et al. showed that MALDI-TOF MS system correctly identified 99.8% (2258/2263) to. Read user reviews, compare products & request pricing from manufacturers of MALDI-TOF Systems | MALDI-TOF M MALDI-TOF MS based clinical proteomics 167 CLINPROT - a MALDI-TOF MS based system for biomarker discovery and analysis Thomas Elssner and Markus Kostrzewa Bruker Daltonik GmbH, Leipzig, Germany. MALDI-TOF systems can provide identification of a larger number of mycobacteria to the species level than HPLC and the AccuProbe system. Turnaround time would also be decreased. In the bacteriology unit, MALDI-TOF would replace conventional biochemicals, commercial identification system and 16s DNA gene sequencing. The initial capital investment for a MALDI-TOF system is high, but the cost per.

MALDI-TOF bacterial identification system - MALDI Biotyper

Bruker MALDI Biotyper Microbiology Systems Beckman Coulte

  1. Use of the MALDI BioTyper system with MALDI-TOF mass spectrometry for rapid identification of microorganisms. Kazuyuki Sogawa 1, Masaharu Watanabe 2, Kenichi Sato 2, Syunsuke Segawa 2, Chisato Ishii 2, Akiko Miyabe 2, Syota Murata 2, Tomoko Saito 2 & Fumio Nomura 1,2,3 Analytical and Bioanalytical Chemistry volume 400, Article number: 1905 (2011) Cite this article. 2746 Accesses. 118.
  2. i-1, from the affordable linear system to TOF-TOF systems in the AXIMA family, ending with the high-end MALDI-7090 covering high-throughput and MS imaging. The uncompromised design offers a robust platform for all needs (polymers.
  3. i mal or no fragmentation. MALDI provides an alternative analysis pathway for molecules not suited for other mass spectrometry techniques.
  4. MALDI TOF Mass Spectrometry Identification Seng et al. Clin Infect Dis. 2009;49:543 Routine phenotypic identification, no. of isolates MALDI TOF identification Species identification No identification Misidentification Total Species identification 1392 4 1 1397 Genus identification 185 2 2 189 No identification 18 26 2 46 Misidentification 27 0.
  5. MALDI-TOF Mass Spectrometer System Site Preparation Specification Issued: April 1995 - Rev. 1.0 PN# G2030-90001 CAD Product Support Page 1 of 1 Purpose of Procedure To assure that the installation of instruments and systems can be completed successfully by careful preparation and evaluation of the installation site and by ensuring the availability of appropriate utilities, consumables and.
  6. iv G1974A PDF-MALDI Installation Guide Step 4. Check the Target Plate alignment 99 Step 5. Center the matrix spot 100 Step 6. Calibrate the Video Capture sample-positioning system 103 Step 7. Verify the installation 108 3 Reference PDF-MALDI Method Settings for LC/MSD Trap SL, XCT, or XCT Plus 114 Default setting for an MS method 11
  7. Configuration examples for MALDI sample preparation - from standard systems to fully automated setups. There is a localized version of this page for your country. English Stay here . English (US) Stay here . German Stay here . English (IN) Stay here . Search Menu . Products.

bioMérieux gibt die CE-Kennzeichnung des neuen MALDI-TOF

Microbial Identification Bruke

MALDI-TOF mass spectrometry: an emerging technology for

  1. Autof ms1000 MALDI - TOF. Previous. Next. The Autof ms1000 is a Matrix Assisted Laser Desorption Ionisation-Time of Flight mass spectrometry microbial identification system. MALDI's purpose is to fire a laser on to the co-crystallisation film formed by the target plate samples and matrix. The matrix absorbs energy from the laser and transmits it to the sample, heating up and vaporising a.
  2. Zusammenfassend stellt das neue Bruker-rapifleX MALDI-TOF System einen Paradigmenwechsel im Hinblick auf Produktivität, Kosten des Besitzes und Benutzerfreundlichkeit dar. Die Bruker-rapifleX Plattform bietet ein komplettes Kennzeichnungssystem mit beispielloser Geschwindigkeit der Analyse und der Leistung an ; Der globale MALDI-TOF-Massenspektrometer-Marktprognosebericht 2021-2027 bietet.
  3. HOCHWERTIGES MASSENSPEKTROMETER - AB Sciex - Voyager DE-Pro MALDI ToF - EUR 1.385,00. ZU VERKAUFEN! Gebrauchtes Massenspektrometer - AB Sciex - Voyager DE-Pro MALDI ToF. Massenspektrometer Voyager 39351925260
  4. Finden Sie Top-Angebote für Applications of MALDI-TOF Spectroscopy bei eBay. Kostenlose Lieferung für viele Artikel
  5. MALDI-TOF system is a soft ionization technique that allows ionization and vaporization of large nonvolatile biomolecules such as intact proteins [8]. The proteins ionized and generated during the MALDI process, are structural proteins, DNA-or RNA-binding proteins and ribosome modulation factors that produce spectral fingerprints that vary between microorganisms and that have peaks specific.
  6. Researchers at UNC Health Care have found that using MALDI-TOF based systems for identifying bacteria and fungi in patient specimens led to a 92 percent cost reduction in the reagents needed to run clinical microbiology tests. During the year-long study, the MALDI-TOF MS technology was also found to take much less time. In most cases, lab technologists identified a pathogen in about an hour.

maldi-tof ms system Search Results. About; News; Press Release; Team; Advisors; Partners; Contact; Bioz Stars; Bioz vStars; maldi tof mass spectrometry (Bruker Corporation) 99. Bruker Corporation maldi tof mass spectrometry Maldi Tof Mass Spectrometry, supplied by Bruker Corporation, used in various techniques. Bioz Stars score: 99/100, based on 1 PubMed citations. ZERO BIAS - scores, article. Beide Systeme stellen eine kosteneffektive Alternative zu konventio­nellen Kulturverfahren wie auch den molekularbiologischen Methoden dar. Vor- und Nachteile Der große Vorteil von MALDI-TOF-MS liegt in der Verwendung eines einzigen analytischen Geräts, das zur Differenzierung von Bakterien und Pilzen genutzt werden kann. Die Ergebnisse. Ionisation -Time of Flight (MALDI-TOF) mass spectrometry used to detect and characterize mixtures of organic molecules. •In micro used as a rapid, accurate and cost-effective method for ID of microbes •2 commercially available: •Vitek MS (bioMerieux) •MALDI Biotyper CA system (Bruker Daltonics) Bruker, MBT Compass User Manual, 201 MALDI-TOF MS technology enables clear and accurate identification at the species, group, or genus level in minutes. The VITEK ® MS system has long been capable of reliably identifying numerous bacteria and yeasts for aiding in clinical diagnosis, and rapid identification of mycobacteria 1 , Nocardia and moulds is an important expansion 77 thus high-throughput performances of these MALDI-TOF MS systems for bacterial ID in 78 clinical laboratories, using duplicate deposit on MALDI target (4, 5, 7, 9, 15, 20, 24). 79 The objective of the present study was to evaluate the performances and technical 80 praticability of the VITEK MS system (bioMérieux), a recently commercialized MALDI- 81 TOF-based method using an original.

The first commercialization of MALDI-TOF MS by Shimadzu began in 1988 with the launch of the LAMS-50k. This was not only the first commercially available MALDI-TOF mass spectrometer, but also enabled detection of polymers and biomolecules up to 100,000 Daltons, a previously unachievable feat by mass spectrometric methods System. Beim Wiederanfahren werden dann alle Behälter automatisch an ihr ursprüngliches Ziel verteilt. Allerdings ist es möglich, mittels MALDI-TOF direkt aus positiven Blutkulturen den Erreger zu bestimmen, um hier noch einmal einen Tag schneller zu sein. (Auch hier muss die Blutkultur erst bebrüte Wie das MALDI-TOF-System funktioniert Massenspektrometrie ist eine Analyse-technik um mittels eines Spektrome-ters die Molekularmasse freier Ionen im Vakuummilieu zu messen. Aus-gangspunkt im Gerät ist die Ionen-quelle bei welcher der Analyt einen Strahl gasförmiger Ionenliefert. Der Massenanalyser trennt die Ionen dann gemäss ihrem m/z-Verhältnis auf und der Detektor erstellt in der Folge. VITEK ® MS Mass spectrometry microbial identification system. VITEK ® MS is an automated mass spectrometry microbial identification system that uses Matrix Assisted Laser Desorption Ionization Time-of-Flight (MALDI-TOF) technology. VITEK ® MS contains a comprehensive IVD-CE marked database for bacteria and fungi, including mycobacteria, Nocardia and moulds Evaluation der Eignung von MALDI-TOF MS zur mikrobiologischen Diagnostik in der Parodontologie Dissertation zum Erwerb des Doktorgrades der Zahnmedizin an der Medizinischen Fakultät der Ludwig-Maximilians-Universität zu München vorgelegt von Stefanie Lindner aus Friedberg 2019 . 2 2 M it G e n e h m ig u n g d e r M e d izi n isch e n F a ku ltl t d e r U n iv e rsi tl t M n ch e n Be rich.

Five Facts About the MALDI Biotyper Beckman Coulte

Matrix-assisted laser desorption/ionization - Wikipedi

Bruker Announces US FDA Clearance of Expanded 3rd ClaimUWO MALDI MS FacilityMALDI imaging mass spectrometryAparatura i zakres badań | Wydział Chemii

Robust and easy-to-use MALDI-TOF system. Integrated CompassTM software for intuitive operation by expert and non-expert users alike. Patented AnchorChipTM MALDI target technology for fast automated acquisition and a 10-100 fold sensitivity increase. ClinProTools bioinformatics system for smart visualization of large numbers of profiles, the creation of predictive models, the validation of. Farfour et al. showed that the MALDI-TOF MS Andromas strategy was reliable to identify a set of 659 Gram-positive rods representing 16 bacterial genera and 72 species by the direct colony method . In that report, Andromas MALDI-TOF MS system could not identify Listeria isolates to the species level because of very similar mass spectra Both MALDI-TOF MS systems could accurately identify 98.3% of the isolates at the species level (1359/1383 for Andromas™; 1360/1383 for Bruker Biotyper™) vs. 96.5% for conventional techniques. Furthermore, whereas conventional methods failed to identify rare or emerging species, these were correctly identified by MALDI-TOF MS. Both MALDI-TOF MS systems are accurate and cost-effective. A relevant set of not experimentally infected individuals (control) is required for differential analysis by MALDI-TOF-MS or RP-HPLC in order to discriminate between immune-induced molecules and constitutively present substances (19). This is a prerequisite when no in vitro assays are used to select the bioactive peptides from the immune system of the model invertebrate investigated